English conference proceeding
Theunissen,
N.C.M., Kamp, G., Koopman, H.M., Zwinderman, A.H., Vogels, A.G.C., &
Wit, J.M. (2000). Quality of life in children treated for idiopathic
short stature: a two year controlled randomized follow-up study. Hormone Research, 53(suppl 2), 46-46.
Abstract
Objective. Changes in Health Related Quality of Life (HRQoL) and self-esteem
were studied in children with idiopathic short stature (ISS) participating
in a prospective randomized controlled study on the effect of Growth Hormone
(GH) treatment.
Sample and methods. The sample consisted of 33 prepubertal children (age
4 to 10 years old at start) with ISS (height < -2 SD). The children
were randomly assigned to a treatment or control group. The children of
the GH treatment group underwent an extensive biochemical assessment to
verify their GH responsiveness during the first year. Thereafter, high
dose GH therapy (6 IU/m2.d) (Pharmacia & Upjohn, Stockholm, Sweden)
was started and given for at least for two years.
HRQoL and self-esteem were assessed three times: shortly after randomization
(T1), after one (T2) and two years (T3). Children with ISS, their parents
and the paediatrician completed questionnaires. These results were compared
to those of a large and representative population sample.
Results. At T1, children with ISS did not have a lower HRQoL and self-esteem
than the norm population, except for social functioning as reported by
child and parents. Children, parents and paediatrician assessed changes
differently: although the paediatrician reported an improvement of HRQoL
and self-esteem in the children treated for short stature, the parents
reported no change, and the children in the treatment group reported the
same or sometimes even worse HRQoL or self-esteem than the control group.
According to linear regression analyses, changes in HRQoL and self esteem
between T2 and T3 hardly related to growth (objectively measured or as
perceived by the child). Instead, changes in several HRQoL and self-esteem
scales related to the height appreciation by the child her/himself.
Conclusions. The assumption that GH treatment improves HRQoL in children
with ISS could not be supported in this study.
Keywords
health related quality of life; health
status; self-esteem; idiopathic short stature; growth hormone treatment;